They help researchers and doctors find out if a new treatment or a new way of providing care:. They can also look at what causes pancreatic cancer, how to prevent it and find better ways to diagnose it.
Most pancreatic cancer trials are looking at different treatment options. They aim to find better treatments that can help people live longer and improve the quality of their daily life. To read more about clinical trials, download our fact sheet, Clinical Trials for pancreatic cancer. Email us at publications pancreaticcancer. Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U.
Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Phase 2. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Actual Study Start Date :. Actual Primary Completion Date :. Estimated Study Completion Date :. But ImmunityBio creates targeted, personalized immunotherapies that are designed to strengthen the immune system and enable it to outsmart your disease.
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Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as capecitabine, may make tumor cells more sensitive to radiation therapy. Drugs used in chemotherapy, such as gemcitabine hydrochloride, capecitabine, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays to kill tumor The purpose of this study is to evaluate the side effects and how well the combination of binimetinib and encorafenib work in treating patients with pancreatic cancer with a somatic BRAF VE mutation.
Binimetinib and encorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving binimetinib and encorafenib may work better compared to the usual treatment in treating patients with pancreatic cancer and a somatic BRAF VE mutation. The purpose of this study is to evaluate the safety and effectiveness of the NanoKnife System for the ablation of unresectable Stage 3 pancreatic adenocarcinoma Stage 3 pancreatic cancer.
The purpose of this study is to evaluate how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed resected and has a pathogenic mutation in BRCA1, BRCA2, or PALB2.
PARP inhibitors are a type of targeted therapy. The purpose of this study is to evaluate the lateral flow assay LFA to be used in conjunction with imaging and existing biomarkers in diagnosed or at-risk-for pancreatic cancer patients. The purpose of this study is to to evaluate the rate of overall survival OS at two years in patients with either borderline or locally advanced pancreatic cancer who receive electron beam intraoperative radiation therapy IORT following chemotherapy and radiation therapy.
Aim 1: To determine the prevalence of pancreas solid tumor intratumoral microbiota, their composition and diversity in specimens prospectively acquired via endoscopic ultrasound EUS. Aim 2: To investigate both the oral and duodenal microbiome of such patients to evaluate for similarities and differences.
This phase I trial studies the side effects and the best dose of sirolimus when given together with vismodegib in treating patients with solid tumors or pancreatic cancer that is metastatic or cannot be removed by surgery. Sirolimus and vismodegib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The purpose of this study is to assess the best 2-year overall survival when comparing fluorouracil, irinotecan hydrochloride, and oxaliplatin combination chemotherapy to gemcitabine hydrochloride and nab-paclitaxel, given before surgery for treating patients who have pancreatic cancer that can be removed by surgery.
Drugs used in chemotherapy, such as fluorouracil, irinotecan hydrochloride, oxaliplatin, gemcitabine hydrochloride, and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug combination chemotherapy may kill more tumor cells.
It is not yet known whether combination chemotherapy The purpose of this study is to determine if TH combined with Gemcitabine versus Gemcitabine alone is as safe and effective in the treatment of patients who have first-line metastatic pancreatic adenocarcinoma. The purpose of this research study is to determine the highest safe dose of study drug that may be used when it is given together with a chemotherapy drug to patients with cancer of the pancreas.
The purpose of this study is to evaluate survival of patients with resectable, borderline resectable pancreatic cancer BRPC and locally advanced pancreatic cancer LAPC separately and as a group.
The primary purpose of this study is to develop a cohort biobank of biospecimens and data of individuals aged 50 and older without pancreatic cancer who are members of kindreds containing three blood relatives with pancreatic cancer, OR who carry a mutation in a known predisposition gene for pancreatic cancer.
This study aims to facilitate discovery and validation of tests for early detection in subjects at high risk for pancreatic ductal adenocarcinoma PDAC. The study also aims to provide a platform for development of an interventional protocol for early detection of PDAC. In addition, we will define the quantitative thresholds for early chemotherapy switch in patients who do not respond to first-line chemotherapy. This phase I trial studies the side effects and best dose of gemcitabine hydrochloride in treating patients with locally advanced pancreatic cancer.
Drugs used in chemotherapy, such as gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Does pancreas enzyme replacement PERT decrease weight loss and improve quality of life in patients with unresectable pancreatic cancer? To determine whether a surveillance program consisting of in a cohort of high-risk individuals results in an excess number of detected and surgically resected high-grade premalignant lesions and early stage pancreatic cancers compared to the natural disease development and manifestation.
To determine whether above mentioned strategy results in an improved survival compared to high-risk individuals not under surveillance and compared to the survival statistics of sporadic pancreatic cancer. To determine patient and lesion characteristics by which precursor lesions can be stratified according Investigators hypothesize that providing dignity therapy to this population will be feasible.
The purpose of this study is to develop a blood test to distinguish various causes of diabetes by evaluating patients who have developed diabetes within the last 3 years, but we will also enroll a small number of patients with long-term diabetes and normal blood sugars for comparison.
Diabetes mellitus is a common condition which is defined by persistently high blood sugar levels. This is a frequent problem that is most commonly due to type 2 diabetes. However, it is now recognized that a small portion of the population with diabetes have an underlying problem with their pancreas, such as The primary purpose of this study is to select and validate candidate methylated DNA markers MDMs individually and in combined panels for the detection of pancreative ductal adenocarcinoma PDAC.
The purpose of this study is to evaluate the effectiveness and safety of the NanoKnife System when used for the ablation of Stage 3 pancreatic adenocarcinoma Stage 3 PC. The purpose of this study is to develop and test a method for early detection of pancreatic cancer by analyzing genetic changes from pancreatic juice.
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